Rekombinanter Cyclin B1 Antikörper (full length)
Kurzübersicht für Rekombinanter Cyclin B1 Antikörper (full length) (ABIN7878061)
Target
Alle Cyclin B1 (CCNB1) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
Klon
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Bindungsspezifität
- full length
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Verwendungszweck
- Cyclin B1 Antibody (azide and preservative free)
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Aufreinigung
- Protein A/G affinity
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Immunogen
- Recombinant full-length human CCNB1 protein was used as the immunogen for the Cyclin B1 antibody.
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Isotyp
- IgG, kappa
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anti-Cyclin B1 (CCNB1) (C-Term) antibody
CCNB1 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) antibodyCCNB1 Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) antibodyCCNB1 Reaktivität: Human, Maus IHC Wirt: Maus Monoclonal CCNB1-1098 unconjugated
anti-Cyclin B1 (CCNB1) (C-Term) antibodyCCNB1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) (AA 1-21) antibodyCCNB1 Reaktivität: Human, Maus, Hamster WB, IHC, FACS, IP, BI, FM Wirt: Maus Monoclonal GNS-1 unconjugated
anti-Cyclin B1 (CCNB1) (AA 1-433) antibodyCCNB1 Reaktivität: Human WB, PLA Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) (AA 271-433) antibodyCCNB1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Huhn WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) antibodyKD Validated CCNB1 Reaktivität: Human WB, FACS, ICC Wirt: Kaninchen Monoclonal 23GB1670 unconjugated Recombinant Antibody
anti-Cyclin B1 (CCNB1) (AA 1-383) antibodyCCNB1 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ELISA, FACS, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin B1 (CCNB1) (AA 1-433) antibodyCCNB1 Reaktivität: Human WB, IF, FACS, ICC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal dilution of the Cyclin B1 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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Konservierungsmittel
- Azide free
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the Cyclin B1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Cyclin B1 (CCNB1)
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Andere Bezeichnung
- Cyclin B1
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Hintergrund
- It recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
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UniProt
- P14635
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Pathways
- Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase
Target
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