Rekombinanter beta Catenin Antikörper (full length)
Kurzübersicht für Rekombinanter beta Catenin Antikörper (full length) (ABIN7877828)
Target
Alle beta Catenin (CATNB) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
Klon
-
-
Bindungsspezifität
- full length
-
Verwendungszweck
- Recombinant Beta Catenin Antibody (azide and preservative free)
-
Aufreinigung
- Protein A affinity
-
Immunogen
- Recombinant full-length human Beta Catenin protein was used as the immunogen for the recombinant Beta Catenin antibody.
-
Isotyp
- IgG, kappa
-
-
-
-
Applikationshinweise
- Optimal dilution of the recombinant Beta Catenin antibody should be determined by the researcher.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
Konservierungsmittel
- Azide free
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Aliquot the recombinant Beta Catenin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- beta Catenin (CATNB) (Catenin, beta (CATNB))
-
Andere Bezeichnung
- Beta Catenin
-
Hintergrund
- Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
-
UniProt
- P35222
-
Pathways
- Peptide Hormone Metabolism
Target
-