Rekombinanter TARDBP Antikörper (C-Term)

Produktnummer ABIN7877485

Der Kaninchen Monoklonal anti-TARDBP Antikörper (Klon TARDP-9299R) (ABIN7877485) detektiert spezifisch TARDBP in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter TARDBP Antikörper (C-Term) (ABIN7877485)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TARDP-9299R

Produktdetails anti-TARDBP Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant TDP43 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant TDP43 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: TDP43

Hintergrund: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion