Fibrillarin Antikörper (AA 77-138)

Produktnummer ABIN7876758

Der Kaninchen Polyklonal anti-Fibrillarin Antikörper wird verwendet zum Nachweis von Fibrillarin in Proben von Human und Affe. Er wurde validiert für WB, IF, ELISA und FACS.

Kurzübersicht für Fibrillarin Antikörper (AA 77-138) (ABIN7876758)

Target: Fibrillarin (FBL)

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibrillarin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Produktdetails anti-Fibrillarin Antikörper

Bindungsspezifität: AA 77-138

Verwendungszweck: FBL Antibody / Fibrillarin

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids K77-N138) was used as the immunogen for the FBL antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FBL antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FBL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Fibrillarin

Target: Fibrillarin (FBL)

Andere Bezeichnung: FBL

Hintergrund: RRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene. This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

UniProt: P22087

Pathways: Ribonucleoside Biosynthetic Process