LDLR Antikörper (AA 705-860)

Produktnummer ABIN7876593

Der Kaninchen Polyklonal anti-LDLR Antikörper wird verwendet zum Nachweis von LDLR in Proben von Human. Er wurde validiert für WB, ELISA und FACS.

Kurzübersicht für LDLR Antikörper (AA 705-860) (ABIN7876593)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LDLR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-LDLR Antikörper

Bindungsspezifität: AA 705-860

Verwendungszweck: LDLR Antibody / LDL Receptor

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids A705-A860) was used as the immunogen for the LDLR antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LDLR antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the LDLR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Andere Bezeichnung: LDLR

Hintergrund: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low absorbance lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low absorbance lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism