Rekombinanter Thyroperoxidase Antikörper (AA 685-804)

Produktnummer ABIN7876418

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Thyroperoxidase in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Thyroperoxidase Antikörper (AA 685-804) (ABIN7876418)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Thyroperoxidase Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TPO-3813R

Produktdetails anti-Thyroperoxidase Antikörper

Bindungsspezifität: AA 685-804

Verwendungszweck: Recombinant Thyroid Peroxidase Antibody (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 685-804) was used as the immunogen for this TPO antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Thyroid Peroxidase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Andere Bezeichnung: Thyroid Peroxidase

Hintergrund: Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis