Mre11 Antikörper (pSer676) (Cy7)

Produktnummer ABIN744164

Der Kaninchen Polyklonal Anti-Mre11-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, Mre11 in Proben von Human zu detektieren.

Kurzübersicht für Mre11 Antikörper (pSer676) (Cy7) (ABIN744164)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Mre11 Antikörper ist konjugiert mit Cy7

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Mre11 Antikörper (Cy7)

Bindungsspezifität: pSer676

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from rat Mre11 around the phosphorylation site of Ser676

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Andere Bezeichnung: Mre11

Hintergrund:

Synonyms: Mre 11, MRE 11a, MRE 11b, MRE11 homolog 1, MRE11 meiotic recombination 11 homolog A, MRE11a, MRE11b, AT like disease, Ataxia telangiectasia disorder like, Ataxia-telangiectasia disorder-like, ATLD, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, endo/exonuclease Mre11. HNGS1, meiotic recombination S. cerevisiae 11 homolog A, meiotic recombination 11 homolog A S. cerevisiae, meiotic recombination 11 homolog A, M mMRE11A.MRE11_RAT

Background: Mre11 is a component of the MRN complex, which plays a critical role in double-strand break repair (DSB), DNA recombination, maintenance of telomere integrity, and meiosis. Mre11 has both single-strand endonuclease and double strand-specific 3'-5' exonuclease activities. Rad50, another component of the MRN complex, is postulated to bind to DNA ends and hold them in close proximity, thus facilitating searches for regions of sequence homology, and also possibly stimulating the activity of DNA ligases and/or restricting Mre11 activity. Mutations in Mre11 may cause breast cancer.

Gen-ID: 4361

Pathways: DNA Reparatur