alpha 2 Macroglobulin Antikörper (AA 604-748)

Produktnummer ABIN7876079

Dieser Maus Monoklonal Antikörper detektiert spezifisch alpha 2 Macroglobulin in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für alpha 2 Macroglobulin Antikörper (AA 604-748) (ABIN7876079)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser alpha 2 Macroglobulin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: A2M-3623

Produktdetails anti-alpha 2 Macroglobulin Antikörper

Bindungsspezifität: AA 604-748

Verwendungszweck: A2M Antibody / Alpha-2-Macroglobulin

Aufreinigung: Protein G affinity chromatography

Immunogen: A portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the A2M antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the A2M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Andere Bezeichnung: A2M

Hintergrund: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

UniProt: P01023

Pathways: Lipid Metabolism