Rekombinanter Thyroperoxidase Antikörper (AA 600-900)

Produktnummer ABIN7876061

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Thyroperoxidase in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Thyroperoxidase Antikörper (AA 600-900) (ABIN7876061)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Thyroperoxidase Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TPO-7088R

Produktdetails anti-Thyroperoxidase Antikörper

Bindungsspezifität: AA 600-900

Verwendungszweck: Thyroid Peroxidase Antibody / TPO

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of human TPO (within amino acids 600-900) was used as the immunogen for the Thyroid Peroxidase antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Thyroid Peroxidase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Andere Bezeichnung: Thyroid Peroxidase

Hintergrund: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis