Rekombinanter Thyroperoxidase Antikörper (AA 600-900)

Produktnummer ABIN7876060

Der Kaninchen Monoklonal anti-Thyroperoxidase Antikörper (Klon TPO-7088R) (ABIN7876060) detektiert spezifisch Thyroperoxidase in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Thyroperoxidase Antikörper (AA 600-900) (ABIN7876060)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Thyroperoxidase Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: TPO-7088R

Produktdetails anti-Thyroperoxidase Antikörper

Bindungsspezifität: AA 600-900

Verwendungszweck: Thyroid Peroxidase Antibody / TPO (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of human TPO (within amino acids 600-900) was used as the immunogen for the Thyroid Peroxidase antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Thyroid Peroxidase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Andere Bezeichnung: Thyroid Peroxidase

Hintergrund: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis