PREX2 Antikörper (AA 582-1094)

Produktnummer ABIN7875864

Der Kaninchen Polyklonal anti-PREX2 Antikörper wird verwendet zum Nachweis von PREX2 in Proben von Human und Maus. Er wurde validiert für ELISA und WB.

Kurzübersicht für PREX2 Antikörper (AA 582-1094) (ABIN7875864)

Target: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PREX2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-PREX2 Antikörper

Bindungsspezifität: AA 582-1094

Verwendungszweck: PREX2 Antibody / DEPDC2

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids D582-Q1094) was used as the immunogen for the PREX2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PREX2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the PREX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PREX2

Target: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Andere Bezeichnung: PREX2

Hintergrund: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, also called DEPDC2 (DEP domain-containing protein 2), is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.

UniProt: Q70Z35