alpha Sarcomeric Actin (AA 557-692) Antikörper

Produktnummer ABIN7875752

Dieser Maus Monoklonal Antikörper detektiert spezifisch alpha Sarcomeric Actin in IHC (p) und WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für alpha Sarcomeric Actin (AA 557-692) Antikörper (ABIN7875752)

Target: alpha Sarcomeric Actin

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Klon: ACTN2-3292

Produktdetails

Bindungsspezifität: AA 557-692

Verwendungszweck: Sarcomeric Alpha Actinin Antibody / ACTN2

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 557-692 from the human protein were used as the immunogen for this Sarcomeric Alpha Actinin antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: The optimal dilution of the Sarcomeric Alpha Actinin antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Sarcomeric Alpha Actinin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: alpha Sarcomeric Actin

Andere Bezeichnung: Sarcomeric Alpha Actinin

Hintergrund: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609