MR1 Antikörper (AA 50-250)

Produktnummer ABIN7875388

Der Maus Monoklonal anti-MR1 Antikörper (Klon MR1-7578) (ABIN7875388) detektiert spezifisch MR1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MR1 Antikörper (AA 50-250) (ABIN7875388)

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MR1-7578

Produktdetails anti-MR1 Antikörper

Bindungsspezifität: AA 50-250

Verwendungszweck: MR1 Antibody / MHC class I related protein 1

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the MR1 antibody.

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MR1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MR1

Target: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Andere Bezeichnung: MR1

Hintergrund: MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.

UniProt: Q95460

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints