ROR2 Antikörper (AA 499-547)

Produktnummer ABIN7875287

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ROR2 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für ROR2 Antikörper (AA 499-547) (ABIN7875287)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-ROR2 Antikörper

Bindungsspezifität: AA 499-547

Verwendungszweck: ROR2 Antibody / Receptor tyrosine kinase-like orphan receptor 2

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human ROR2 recombinant protein (Position: E499-Q547) was used as the immunogen for the ROR2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ROR2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ROR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Andere Bezeichnung: ROR2

Hintergrund: ROR2 antibody detects Receptor tyrosine kinase-like orphan receptor 2, encoded by the ROR2 gene. Receptor tyrosine kinase-like orphan receptor 2 is a transmembrane protein that belongs to the receptor tyrosine kinase family and is an important regulator of development, cell signaling, and skeletal formation. ROR2 antibody provides researchers with a specific reagent for studying Wnt signaling pathways, embryogenesis, and disease processes associated with developmental abnormalities.

Receptor tyrosine kinase-like orphan receptor 2 contains an extracellular cysteine-rich domain, an immunoglobulin-like domain, and a tyrosine kinase-like cytoplasmic domain. Research using ROR2 antibody has shown that it functions as a receptor for non-canonical Wnt signaling, particularly Wnt5a. Activation of ROR2 modulates cytoskeletal dynamics, cell migration, and planar cell polarity signaling. These activities are essential for tissue morphogenesis during development.

Studies with ROR2 antibody have revealed that mutations in the ROR2 gene cause developmental disorders such as Robinow syndrome and brachydactyly type B. These conditions are characterized by skeletal malformations, short stature, and craniofacial abnormalities. Research into patient-derived cells has demonstrated that loss of ROR2 disrupts Wnt signaling, impairing cartilage development and bone growth. These findings highlight the essential role of ROR2 in skeletal patterning.

In cancer biology, ROR2 has emerged as a regulator of tumor progression. Research using ROR2 antibody has demonstrated that ROR2 promotes migration and invasion in melanoma, renal cell carcinoma, and osteosarcoma. Overexpression correlates with poor prognosis, likely due to its ability to activate signaling pathways that remodel the cytoskeleton and extracellular matrix. Targeting ROR2 is under investigation as a therapeutic strategy in oncology.

ROR2 antibody is widely applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting detects full-length receptor and truncated isoforms, immunohistochemistry localizes expression to developing skeletal tissues and tumors, and flow cytometry quantifies receptor surface expression on cells. These applications make ROR2 antibody indispensable for developmental biology and cancer research.

By supplying validated ROR2 antibody reagents, NSJ Bioreagents supports studies into skeletal development, Wnt signaling, and cancer. Detection of Receptor tyrosine kinase-like orphan receptor 2 provides researchers with insights into how receptor tyrosine kinases integrate developmental cues with disease processes.

UniProt: Q01974

Pathways: RTK Signalweg, WNT Signalweg