KIF3A Antikörper (AA 486-701)

Produktnummer ABIN7875231

Der Kaninchen Polyklonal anti-KIF3A Antikörper wird verwendet zum Nachweis von KIF3A in Proben von Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für KIF3A Antikörper (AA 486-701) (ABIN7875231)

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KIF3A Antikörper

Bindungsspezifität: AA 486-701

Verwendungszweck: Zebrafish Kif3a Antibody

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Kif3a recombinant protein (amino acids D486-Q701) was used as the immunogen for the Zebrafish Kif3a antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Kif3a antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Kif3a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu KIF3A

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Andere Bezeichnung: Kif3a

Hintergrund: Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the plus ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

UniProt: E9QB71

Pathways: Hedgehog Signalweg