Perforin 1 Antikörper (AA 413-552)

Produktnummer ABIN7874879

Dieser Maus Monoklonal Antikörper detektiert spezifisch Perforin 1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Perforin 1 Antikörper (AA 413-552) (ABIN7874879)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Perforin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PRF1-2470

Produktdetails anti-Perforin 1 Antikörper

Bindungsspezifität: AA 413-552

Verwendungszweck: Perforin Antibody / PRF1

Aufreinigung: Protein G affinity

Immunogen: A portion of amino acids 413-552 from the human protein was used as the immunogen for the Perforin antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Perforin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Perforin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Andere Bezeichnung: Perforin

Hintergrund: Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.

UniProt: P14222

Pathways: Apoptose, Caspase Kaskade in der Apoptose