Perforin 1 Antikörper (AA 280-555)
Kurzübersicht für Perforin 1 Antikörper (AA 280-555) (ABIN3020642)
Target
Alle Perforin 1 (PRF1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 280-555
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Sequenz
- EEKKKKHKMT ASFHQTYRER HSEVVGGHHT SINDLLFGIQ AGPEQYSAWV NSLPGSPGLV DYTLEPLHVL LDSQDPRREA LRRALSQYLT DRARWRDCSR PCPPGRQKSP RDPCQCVCHG SAVTTQDCCP RQRGLAQLEV TFIQAWGLWG DWFTATDAYV KLFFGGQELR TSTVWDNNNP IWSVRLDFGD VLLATGGPLR LQVWDQDSGR DDDLLGTCDQ APKSGSHEVR CNLNHGHLKF RYHARCLPHL GGGTCLDYVP QMLLGEPPGN RSGAVW
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 280-555 of human Perforin (NP_001076585.1).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid freeze / thaw cycles
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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Andere Bezeichnung
- PRF1
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Hintergrund
- The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.,PRF1,FLH2,HPLH2,P1,PFN1,PFP,perforin-1,Perforin,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,PRF1
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Molekulargewicht
- 61 kDa
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Gen-ID
- 5551
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UniProt
- P14222
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose
Target
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