MSH2 Antikörper (AA 327-427)

Produktnummer ABIN7873978

Der Maus Monoklonal anti-MSH2 Antikörper (Klon MSH2-2622) (ABIN7873978) detektiert spezifisch MSH2 in WB, IF, FACS und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MSH2 Antikörper (AA 327-427) (ABIN7873978)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MSH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MSH2-2622

Produktdetails anti-MSH2 Antikörper

Bindungsspezifität: AA 327-427

Verwendungszweck: MSH2 Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 327-427) was used as the immunogen for this MSH2 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MSH2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the MSH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Andere Bezeichnung: MSH2

Hintergrund: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

UniProt: P43246

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response