PDGFB Antikörper (AA 27-158)

Produktnummer ABIN7873082

Dieser Maus Monoklonal Antikörper detektiert spezifisch PDGFB in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PDGFB Antikörper (AA 27-158) (ABIN7873082)

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDGFB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PDGFB-3071

Produktdetails anti-PDGFB Antikörper

Bindungsspezifität: AA 27-158

Verwendungszweck: PDGF beta Antibody

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 27-158 was used as the immunogen for the PDGF beta antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PDGF beta antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PDGF beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Andere Bezeichnung: PDGF beta

Hintergrund: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF AA, AB and BB. The three isoforms bind, with different affinities, to two receptor types, receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.

UniProt: P01127

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling