ICOSLG Antikörper (AA 23-149)

Produktnummer ABIN7872484

Der Maus Monoklonal anti-ICOSLG Antikörper (Klon ICOSL-3111) (ABIN7872484) detektiert spezifisch ICOSLG in ELISA, FACS, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ICOSLG Antikörper (AA 23-149) (ABIN7872484)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICOSLG Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: ICOSL-3111

Produktdetails anti-ICOSLG Antikörper

Bindungsspezifität: AA 23-149

Verwendungszweck: ICOSLG Antibody / ICOS Ligand / B7RP-1 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant fragment of human ICOS Ligand / B7RP-1 protein within amino acids 23-149 was used as the immunogen for the ICOSLG antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ICOSLG antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the ICOSLG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Andere Bezeichnung: ICOSLG

Hintergrund: This MAb recognizes a protein of 36 kDa, identified as ICOSLG, which is also known as B7-related protein-1 (B7RP-1).T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1, B7-H2, GL50, ICOS-L) is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNFi±), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation