ADAM17 Antikörper (AA 215-449)

Produktnummer ABIN7872232

Der Kaninchen Polyklonal anti-ADAM17 Antikörper (ABIN7872232) detektiert spezifisch ADAM17 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für ADAM17 Antikörper (AA 215-449) (ABIN7872232)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ADAM17 Antikörper

Bindungsspezifität: AA 215-449

Verwendungszweck: Adam17 Antibody

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids R215-M449) was used as the immunogen for the Adam17 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Adam17 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Adam17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Andere Bezeichnung: Adam17

Hintergrund: ADAM17 (ADAM metallopeptidase domain 17), also called TACE (tumor necrosis factor-alpha-converting enzyme), is a 70- kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-a) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-a), and is of known physiological importance. ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

UniProt: Q9Z0F8

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus