KISS1 Antikörper (AA 20-52)

Produktnummer ABIN7871877

Der Kaninchen Polyklonal anti-KISS1 Antikörper wird verwendet zum Nachweis von KISS1 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für KISS1 Antikörper (AA 20-52) (ABIN7871877)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KISS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-KISS1 Antikörper

Bindungsspezifität: AA 20-52

Verwendungszweck: KiSS-1 Antibody / KISS1

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 20-52 from the human protein was used as the immunogen for the KiSS-1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the KiSS-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the KiSS-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Andere Bezeichnung: KiSS-1

Hintergrund: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion