KISS1 Antikörper (AA 20-52)

Produktnummer ABIN6243764

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch KISS1 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KISS1 Antikörper (AA 20-52) (ABIN6243764)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KISS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB53797

Produktdetails anti-KISS1 Antikörper

Bindungsspezifität: AA 20-52

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KISS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 20-52 amino acids from human KISS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:2000. WB: 1:500. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Andere Bezeichnung: KISS1

Hintergrund: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Molekulargewicht: 14705

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion