MPG Antikörper (AA 20-298)

Produktnummer ABIN7871858

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MPG in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MPG Antikörper (AA 20-298) (ABIN7871858)

Target: MPG (N-Methylpurine-DNA Glycosylase (MPG))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-MPG Antikörper

Bindungsspezifität: AA 20-298

Verwendungszweck: DNA-3-methyladenine glycosylase Antibody / MPG / AAG

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q20-A298) was used as the immunogen for the DNA-3-methyladenine glycosylase antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DNA-3-methyladenine glycosylase antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DNA-3-methyladenine glycosylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MPG

Target: MPG (N-Methylpurine-DNA Glycosylase (MPG))

Andere Bezeichnung: DNA-3-methyladenine glycosylase

Hintergrund: MPG (N-methylpurine-DNA glycosylase) also known as MDG, 3-METHYLADENINE DNA GLYCOSYLASE, 3MeAde DNA GLYCOSYLASE, AAG and APNG is a protein expressed in all cell lines and tissues examined, but was found at particularly high levels in a colon adenocarcinoma cell line(HT29). The completely characterized human MPG gene was found to span 7 to 8 kb of genomic DNA and to be localized 75 kb upstream of the embryonic zeta-globin gene. To assess the contribution of Apng to the repair of several mutagenic lesions in vivo,Hang et al.(1997)biochemically analyzed cell-free extracts of tissues from mice with a targeted deletion of the Apng gene. Following treatment with DNA-methylating agents, increased persistence of 7-methylguanine (meG) was found in liver sections of APNG knockout mice in comparison with wildtype mice, demonstrating an in vivo phenotype for the APNG-null animals.

UniProt: P29372

Pathways: DNA Reparatur