Dystrophin Antikörper (AA 1700-2300)

Produktnummer ABIN7871257

Der Maus Monoklonal anti-Dystrophin Antikörper (Klon DMD-6270) (ABIN7871257) detektiert spezifisch Dystrophin in WB, IHC (p) und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Dystrophin Antikörper (AA 1700-2300) (ABIN7871257)

Target: Dystrophin (DMD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dystrophin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Güteklasse: Carrier-free

Klon: DMD-6270

Produktdetails anti-Dystrophin Antikörper

Bindungsspezifität: AA 1700-2300

Verwendungszweck: DMD Antibody / Dystrophin (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 1700-2300 from the human Dystrophin was used as the immunogen for the DMD antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DMD antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DMD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Dystrophin

Target: Dystrophin (DMD)

Andere Bezeichnung: DMD

Hintergrund: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development