Rekombinanter Topoisomerase II alpha Antikörper (AA 1431-1531)

Produktnummer ABIN7870711

Der Kaninchen Monoklonal anti-Topoisomerase II alpha Antikörper (Klon TOP2A-7169R) (ABIN7870711) detektiert spezifisch Topoisomerase II alpha in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Hund.

Kurzübersicht für Rekombinanter Topoisomerase II alpha Antikörper (AA 1431-1531) (ABIN7870711)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Hund

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Topoisomerase II alpha Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TOP2A-7169R

Produktdetails anti-Topoisomerase II alpha Antikörper

Bindungsspezifität: AA 1431-1531

Verwendungszweck: Topoisomerase II alpha Antibody / TOP2A

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1431-1531) from the human protein was used as the immunogen for the Topoisomerase II alpha antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Topoisomerase II alpha antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Topoisomerase II alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Andere Bezeichnung: Topoisomerase II alpha

Hintergrund: The topoisomerase II-Alpha isoform is a 170 kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-Alpha is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-Alpha is the predominant mechanism of resistance to several chemotherapeutic agents.

UniProt: P11388

Pathways: Zellzyklus, Mitotic G1-G1/S Phases