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Topoisomerase II alpha Antikörper (AA 1100-1530)

TOP2A Reaktivität: Human, Ratte WB, ELISA, FACS, ICC Wirt: Maus Monoclonal 6C12G12 unconjugated
Produktnummer ABIN7193564
  • Target Alle Topoisomerase II alpha (TOP2A) Antikörper anzeigen
    Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
    Bindungsspezifität
    • 19
    • 18
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1100-1530
    Reaktivität
    • 147
    • 61
    • 29
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Human, Ratte
    Wirt
    • 111
    • 37
    Maus
    Klonalität
    • 97
    • 51
    Monoklonal
    Konjugat
    • 73
    • 11
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Topoisomerase II alpha Antikörper ist unkonjugiert
    Applikation
    • 99
    • 56
    • 51
    • 48
    • 26
    • 18
    • 13
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human TOP2A (AA: 1100-1530) expressed in E. coli.
    Klon
    6C12G12
    Isotyp
    IgG2b
    Top Product
    Discover our top product TOP2A Primärantikörper
  • Applikationshinweise
    WB:1:500 - 1:2000, ICC:1:100 - 1:500, FCM:1:200 - 1:400, ELISA:1:10000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Target
    Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
    Andere Bezeichnung
    TOP2A (TOP2A Produkte)
    Synonyme
    TOP2 antikoerper, TP2A antikoerper, TOP2A antikoerper, Top-2 antikoerper, TOP-2 antikoerper, F12B17.110 antikoerper, F12B17_110 antikoerper, thimet metalloendopeptidase 2 antikoerper, fc08c07 antikoerper, wu:fc08c07 antikoerper, DNA topoisomerase II alpha antikoerper, DNA topoisomerase II, alpha isozyme antikoerper, topoisomerase (DNA) II alpha antikoerper, Zincin-like metalloproteases family protein antikoerper, TOP2A antikoerper, Bm1_08705 antikoerper, Top2a antikoerper, AT5G10540 antikoerper, top2a antikoerper
    Hintergrund

    Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

    Aliases: TOP2, TP2A

    Molekulargewicht
    174.4 kDa
    Gen-ID
    7153
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases
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