TP53BP1 Antikörper (AA 1239-1972)

Produktnummer ABIN7870362

Der Kaninchen Polyklonal anti-TP53BP1 Antikörper wird verwendet zum Nachweis von TP53BP1 in Proben von Human. Er wurde validiert für WB, ELISA, IF, FACS und IHC (p).

Kurzübersicht für TP53BP1 Antikörper (AA 1239-1972) (ABIN7870362)

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TP53BP1 Antikörper

Bindungsspezifität: AA 1239-1972

Verwendungszweck: P53 binding protein 1 Antibody / 53BP1

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids H1239-H1972) was used as the immunogen for the p53 binding protein 1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the p53 binding protein 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the p53 binding protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Andere Bezeichnung: P53 binding protein 1

Hintergrund: TP53BP1 (Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

UniProt: Q12888

Pathways: DNA Reparatur