TP53BP1 Antikörper

Produktnummer ABIN1679832

Der Kaninchen Monoklonal anti-TP53BP1 Antikörper (ABIN1679832) detektiert spezifisch TP53BP1 in IHC, WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TP53BP1 Antikörper (ABIN1679832)

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TP53BP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-TP53BP1 Antikörper

Kreuzreaktivität: Human, Maus

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human 53BP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Andere Bezeichnung: TP53BP1

Hintergrund: Double-strand break (DSB repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub and histone H4 dimethylated at 'Lys-20' (H4K20me2, two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR during antibody genesis, a process that involves the generation of DNA DSBs. Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity. In contrast, it is not required for classic NHEJ and V(DJ recombination (By similarity. Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.,53BP1, TDRD30, TP53, p202, p53BP1,Cancer,DNA Damage & Repair,Epigenetics & Nuclear Signaling,Protein phosphorylation,Tumor suppressors,Tumor suppressors_p53 pathway,TP53BP1

Molekulargewicht: 450 kDa

Gen-ID: 7158

UniProt: Q12888

Pathways: DNA Reparatur