Rekombinanter MUC16 Antikörper (AA 12201-12300)

Produktnummer ABIN7870342

Der Kaninchen Monoklonal anti-MUC16 Antikörper (Klon OCA125-4505R) (ABIN7870342) detektiert spezifisch MUC16 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter MUC16 Antikörper (AA 12201-12300) (ABIN7870342)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MUC16 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: OCA125-4505R

Produktdetails anti-MUC16 Antikörper

Bindungsspezifität: AA 12201-12300

Verwendungszweck: Recombinant MUC16 Antibody / CA125

Aufreinigung: Protein A affinity chromatography

Immunogen: A portion of amino acids 12201-12300 from the human protein was used as the immunogen for the recombinant MUC16 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant MUC16 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant MUC16 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: MUC16

Hintergrund: CA125 also known as mucin 16, is a member of the mucin family glycoproteins. CA125 is a component of the ocular surface (including the cornea and conjunctiva), the respiratory tract and the female reproductive tract epithelia. Since CA125 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. CA125 reacts with both normal tissues and neoplasms of fallopian tube, endometrium, endocervix and mesothelioma. It does not react with colon cancer. Normal tissues such as breast, liver, skin, kidney and spleen are also negative. Studies have shown that CA125 reacts with approximately 80 % of epithelial ovarian neoplasms of serous, endometrioid, clear cell and undifferentiated types. No reactivity has been shown for mucinous ovarian tumors or in germ cell or hematopoietic tumors. This antibody is a useful aid for classification of a variety of tumors, such as some adenocarcinomas of the colon, breast carcinomas, malignant mesothelioma, uterine adenomatoid tumor, lung bronchoalveolar carcinoma, and ovarian endometrioid and serous carcinomas.

UniProt: Q8WXI7