ATG5 Antikörper (AA 118-155)

Produktnummer ABIN7870256

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ATG5 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für ATG5 Antikörper (AA 118-155) (ABIN7870256)

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ATG5 Antikörper

Bindungsspezifität: AA 118-155

Verwendungszweck: Zebrafish Atg5 Antibody / Autophagy protein 5

Aufreinigung: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Atg5 recombinant protein (amino acids S118-L155) was used as the immunogen for the Zebrafish Atg5 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Atg5 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Atg5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ATG5

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Andere Bezeichnung: Atg5

Hintergrund: Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene. It is also known as APG5 or ASP, and this gene is mapped to 6q21. It is found that knockdown of ATG5 in hepatocytes increased triglyceride levels with oleate or a second endogenous stimulus for triglyceride formation. These hepatocytes with ATG5 knockdown also had increased lipid droplet number and size. ATG5 is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.

UniProt: F1RDC0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagie