Dystrophin Antikörper (AA 114-263)

Produktnummer ABIN7870179

Der Maus Monoklonal anti-Dystrophin Antikörper wird verwendet zum Nachweis von Dystrophin in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für Dystrophin Antikörper (AA 114-263) (ABIN7870179)

Target: Dystrophin (DMD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dystrophin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: DSTN-1

Produktdetails anti-Dystrophin Antikörper

Bindungsspezifität: AA 114-263

Verwendungszweck: Dystrophin Antibody / DMD (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 114-263 from the human protein were used as the immunogen for the Dystrophin antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Dystrophin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Dystrophin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Dystrophin

Target: Dystrophin (DMD)

Andere Bezeichnung: Dystrophin

Hintergrund: The DMD gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [RefSeq]

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development