PAX6 Antikörper (AA 1-401)

Produktnummer ABIN7869319

Der Kaninchen Polyklonal anti-PAX6 Antikörper (ABIN7869319) detektiert spezifisch PAX6 in WB und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Zebrafisch (Danio rerio).

Kurzübersicht für PAX6 Antikörper (AA 1-401) (ABIN7869319)

Target: PAX6 (Paired Box 6 (PAX6))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAX6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PAX6 Antikörper

Bindungsspezifität: AA 1-401

Verwendungszweck: Zebrafish Pax6 Antibody / Pax6a / Pax6b

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Pax6 recombinant protein (amino acids M1-M401) was used as the immunogen for the Zebrafish Pax6 antibody. This antibody will detect isoforms a & b.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Pax6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Pax6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Andere Bezeichnung: Pax6

Hintergrund: Paired box protein 6 (Pax6) is a highly conserved transcription factor that plays a central role in the development of the eye, central nervous system, and pancreas. In zebrafish (Danio rerio), Pax6 is encoded by two paralogous genes, pax6a and pax6b, both of which are essential for ocular morphogenesis, neurogenesis, and endocrine cell differentiation.

During embryogenesis, zebrafish Pax6 is expressed in the forebrain, optic vesicles, retina, and spinal cord, where it regulates the expression of genes critical for cell fate determination and tissue patterning. Pax6 is a key regulator of eye field specification and is required for the proper formation of structures such as the lens, retina, and optic tectum. In addition, it contributes to pancreatic islet cell development, particularly in the differentiation of insulin-producing Beta-cells.

Given its evolutionary conservation and well-characterized functions, zebrafish Pax6 is widely used as a model for studying ocular development, neural differentiation, congenital eye disorders (e.g., aniridia), and transcriptional control of organogenesis.

UniProt: P26630

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis