DUSP6 Antikörper (AA 1-381)

Produktnummer ABIN7869275

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DUSP6 in WB, ELISA, IF, FACS und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für DUSP6 Antikörper (AA 1-381) (ABIN7869275)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DUSP6 Antikörper

Bindungsspezifität: AA 1-381

Verwendungszweck: DUSP6 Antibody

Aufreinigung: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-T381) was used as the immunogen for the DUSP6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the DUSP6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the DUSP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Andere Bezeichnung: DUSP6

Hintergrund: Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

UniProt: Q16828

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades