DUSP6 Antikörper

Produktnummer ABIN1882185

Zitiert in 3+ Publikationen. Der Kaninchen Polyklonal anti-DUSP6 Antikörper (Klon RB7281) (ABIN1882185) detektiert spezifisch DUSP6 in WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für DUSP6 Antikörper (ABIN1882185)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: RB7281

Produktdetails anti-DUSP6 Antikörper

Aufreinigung: This antibody is purified through a protein A column, followed by dialysis against PBS.

Immunogen: This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DUSP6 Antikörper (ABIN1882185)

Olson, Protheroe, Segar, Scholz: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).

Muda, Boschert, Dickinson, Martinou, Martinou, Camps, Schlegel, Arkinstall: "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 4319-26, (1996) (PubMed).

Mourey, Vega, Campbell, Wenderoth, Hauschka, Krebs, Dixon: "A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation." in: The Journal of biological chemistry, Vol. 271, Issue 7, pp. 3795-802, (1996) (PubMed).

Details zu DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Andere Bezeichnung: MKP3

Hintergrund: Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36 % identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis

Molekulargewicht: 42319

NCBI Accession: NP_446335

UniProt: Q64346

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades