ICOSLG Antikörper (AA 1-300)

Produktnummer ABIN7869127

Der Maus Monoklonal anti-ICOSLG Antikörper (Klon ICOSL-7700) (ABIN7869127) detektiert spezifisch ICOSLG in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ICOSLG Antikörper (AA 1-300) (ABIN7869127)

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICOSLG Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: ICOSL-7700

Produktdetails anti-ICOSLG Antikörper

Bindungsspezifität: AA 1-300

Verwendungszweck: B7RP-1 Antibody / ICOSLG

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of human ICOSLG/B7RP-1 protein (within amino acids 1-300) was used as the immunogen for the B7RP-1 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the B7RP-1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the B7RP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Andere Bezeichnung: B7RP-1

Hintergrund: This mAb recognizes a protein of 36 kDa, identified as ICOS-L, also called B7RP-1 or B7-related protein 1. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF Alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

UniProt: O75144

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation