Rekombinanter IL21 Receptor Antikörper (PE)

Produktnummer ABIN7867339

Der PE-konjugierte Kaninchen Chimeric anti-IL21 Receptor Antikörper (Klon DMC225) (ABIN7867339) detektiert spezifisch IL21 Receptor in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter IL21 Receptor Antikörper (PE) (ABIN7867339)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser IL21 Receptor Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: DMC225

Produktdetails anti-IL21 Receptor Antikörper (PE)

Verwendungszweck: PE-conjugated Anti-IL21R antibody(DMC225), IgG1 Chimeric mAb

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C-8°C for 6 months

Haltbarkeit: 6 months

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: IL21R

Hintergrund:

Synonyms: CD360, IMD56, NILR

Target Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg