Rekombinanter GDNF Antikörper (PE)

Produktnummer ABIN7867287

Der Kaninchen Chimeric anti-GDNF Antikörper wird verwendet zum Nachweis von GDNF in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für Rekombinanter GDNF Antikörper (PE) (ABIN7867287)

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser GDNF Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: DMC498

Produktdetails anti-GDNF Antikörper (PE)

Verwendungszweck: PE-conjugated Anti-GDNF antibody(DMC498), IgG1 Chimeric mAb

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C-8°C for 6 months

Haltbarkeit: 6 months

Details zu GDNF

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Andere Bezeichnung: GDNF

Hintergrund:

Synonyms: ATF, ATF1, ATF2, HFB1-GDNF, HSCR3

Target Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

UniProt: P39905

Pathways: RTK Signalweg, Synaptic Membrane, Tube Formation, Autophagie, Smooth Muscle Cell Migration