MLH1 Antikörper

Produktnummer ABIN7865702

Dieser Maus Monoklonal Antikörper detektiert spezifisch MLH1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MLH1 Antikörper (ABIN7865702)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLH1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: IHC409

Produktdetails anti-MLH1 Antikörper

Verwendungszweck: anti-MLH1 mouse monoclonal, IHC409, purified

Aufreinigung: affinity chromatography

Immunogen: Recombinant Human MLH1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: store at 2 - 8 °C

Details zu MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Andere Bezeichnung: MLH1

Hintergrund: MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable.

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response