MSH2 Antikörper

Produktnummer ABIN7865693

Dieser Maus Monoklonal Antikörper detektiert spezifisch MSH2 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MSH2 Antikörper (ABIN7865693)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MSH2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: IHC410

Produktdetails anti-MSH2 Antikörper

Verwendungszweck: anti-MSH2 mouse monoclonal, IHC410, purified

Aufreinigung: affinity chromatography

Immunogen: Recombinant Human MSH2

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: store at 2 - 8 °C

Details zu MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Andere Bezeichnung: MSH2

Hintergrund: MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response