TIGIT Antikörper

Produktnummer ABIN7862150

Dieser Maus Monoklonal Antikörper detektiert spezifisch TIGIT in ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TIGIT Antikörper (ABIN7862150)

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIGIT Antikörper ist unkonjugiert

Applikation: ELISA

Klon: TIGIT-3033

Produktdetails anti-TIGIT Antikörper

Verwendungszweck: TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer) Antibody

Spezifität: TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TIGIT protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TIGIT

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Andere Bezeichnung: TIGIT

Hintergrund:

T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain containing 9 (VSIG9), V-set and transmembrane domain containing 3 (VSTM3), Washington University cell adhesion molecule (WUCAM)

Molt-4 cells. Human prostate or colon carcinoma.

Molekulargewicht: 26kDa

Gen-ID: 201633, 421750

UniProt: Q495A1

Pathways: Cancer Immune Checkpoints