IL-3 Antikörper

Produktnummer ABIN7864797

Dieser Maus Monoklonal Antikörper detektiert spezifisch IL-3 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL-3 Antikörper (ABIN7864797)

Target: IL-3 (Interleukin 3 (IL-3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: IL3-4003

Produktdetails anti-IL-3 Antikörper

Verwendungszweck: Interleukin-3 (IL-3) Antibody

Spezifität: Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific ± subunit and a signal transducing ≤ subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the ≤ subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human IL3 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu IL-3

Target: IL-3 (Interleukin 3 (IL-3))

Andere Bezeichnung: Interleukin-3

Hintergrund:

Colony stimulating factor multiple, Hematopoietic growth factor, Interleukin 3 (colony stimulating factor, multiple), Mast cell growth factor, MCGF, Multi CSF, Multilineage colony stimulating factor, P cell stimulating factor

Human thymus or tonsil tissue.

Molekulargewicht: 17kDa

Gen-ID: 3562, 694

Pathways: JAK-STAT Signalweg, Regulation of Carbohydrate Metabolic Process, Autophagie