Rekombinanter HLAG Antikörper

Produktnummer ABIN7864109

Der Kaninchen Monoklonal anti-HLAG Antikörper wird verwendet zum Nachweis von HLAG in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter HLAG Antikörper (ABIN7864109)

Target: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HLAG Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: HLAG-8393R

Produktdetails anti-HLAG Antikörper

Verwendungszweck: Recombinant HLA-G (Major Histocompatibility Complex, class I, G) Antibody

Spezifität: Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, é 79oΩ2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Purified His-tagged HLA-G protein.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu HLAG

Target: HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

Andere Bezeichnung: HLA-G

Hintergrund:

B2 microglobulin, DADB-15K14.8, HLA 6.0, HLA G histocompatibility antigen class I G, HLA G3, HLA60, HLAG, Major histocompatibility complex class I G, MHC class I antigen G, MHC G, T-cell A locus, TCA

Human Lungs, Raji cells. Expressed in trophoblasts.

Molekulargewicht: 39kDa

Gen-ID: 3135, 512152

UniProt: P17693

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response