Rekombinanter GSTM3 Antikörper

Produktnummer ABIN7865038

Der Maus Monoklonal anti-GSTM3 Antikörper wird verwendet zum Nachweis von GSTM3 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter GSTM3 Antikörper (ABIN7865038)

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSTM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: RGSTM3-8878

Produktdetails anti-GSTM3 Antikörper

Verwendungszweck: Recombinant Glutathione S-Transferase Mu3 (GSTM3) Antibody

Spezifität: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, namely ±, é 79oΩ, é 79oΩ, é 79oΩ, 79oΩ, è 79oΩ, è 79oΩ and è 79oΩ, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM3 protein is selectively expressed in the testis and brain. GSTM3 may also be tumor suppressive in RCC, as low expression has been demonstrated to correlate with RCC risk and poor prognosis in post-op patients.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human GSTM3 protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu GSTM3

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Andere Bezeichnung: Glutathione S-Transferase Mu3

Hintergrund:

brain GST antibody, brain type mu glutathione S transferase, GST class mu 3, GST5, GSTB, GSTM3-3, S (hydroxyalkyl)glutathione lyase M3, glutathione S transferase M3 (brain)

Brain|T-47D, HeLa cell lysate. Human liver|testis or kidney.

Molekulargewicht: 26kDa

Gen-ID: 2947, 2006

UniProt: P21266