Rekombinanter CDK4 Antikörper (N-Term)

Produktnummer ABIN7860785

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch CDK4 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter CDK4 Antikörper (N-Term) (ABIN7860785)

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CDK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: CDK4-8351R

Produktdetails anti-CDK4 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Recombinant CDK4 Antibody

Spezifität: Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth (PMID:21844184). CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas, but rarely expressed in other benign liposarcomas and other sarcomas. CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+), dedifferentiated liposarcoma (+) and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma and other high-grade sarcomas.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment corresponding to N-terminal of human CDK4 protein

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu CDK4

Target: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Andere Bezeichnung: CDK4

Hintergrund:

CDK4 protein, CDK4_HUMAN, Cell division protein kinase 4, CMM3, Crk3, Cyclin dependent kinase 4, Melanoma cutaneous malignant 3, MGC14458, p34 cdk4, PSK-J3

MCF7, HEK293T, cervical carcinoma and liposarcomas.|Human urothelial carcinoma, HeLa

Molekulargewicht: 34kDa

Gen-ID: 1019, 95577

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size