alpha 2 Macroglobulin Antikörper (AA 600-800)

Produktnummer ABIN7864902

Dieser Maus Monoklonal Antikörper detektiert spezifisch alpha 2 Macroglobulin in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für alpha 2 Macroglobulin Antikörper (AA 600-800) (ABIN7864902)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser alpha 2 Macroglobulin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: A2M-6555

Produktdetails anti-alpha 2 Macroglobulin Antikörper

Bindungsspezifität: AA 600-800

Verwendungszweck: Alpha-2-Macroglobulin Antibody

Spezifität: ±-2-Macroglobulin (±-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, ±-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on ±-2M. This interaction induces a conformational change in ±-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, ±-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor ≤ (TGF≤) in serum is primarily bound to ±-2M, which renders TGF≤ inactive. ±-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding ±-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of ±-2M in mediating the clearance and degradation of A ≤, the major component of ≤-Amyloid deposits accumulated during AD.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human recombinant A2M protein fragment (around aa 600-800) (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Andere Bezeichnung: Alpha-2-Macroglobulin

Hintergrund:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, Alpha-2-M (A2M), CPAMD5

Human liver or placenta tissues.

Molekulargewicht: 185kDa

Gen-ID: 2, 212838

UniProt: P01023

Pathways: Lipid Metabolism