PDGFB Antikörper (AA 27-158)

Produktnummer ABIN7863222

Der Maus Monoklonal anti-PDGFB Antikörper (Klon PDGFB-3071) (ABIN7863222) detektiert spezifisch PDGFB in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PDGFB Antikörper (AA 27-158) (ABIN7863222)

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDGFB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: PDGFB-3071

Produktdetails anti-PDGFB Antikörper

Bindungsspezifität: AA 27-158

Verwendungszweck: PDGF beta (PDGFB) Antibody

Spezifität: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF AA, AB and BB. The three isoforms bind, with different affinities, to two receptor types, °™and æ, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers, the A subunit of PDGF binds only to °™ receptors with high affinity, whereas the B subunit can bind to both °™ and æ receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human PDGFB protein (around aa 27-158) (exact sequence is proprietary)

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Andere Bezeichnung: PDGF beta

Hintergrund:

Becaplermin, c sis, Oncogene SIS, PDGF Beta chain, PDGF2, Platelet derived growth factor 2, Platelet derived growth factor B chain, Platelet derived growth factor beta, Platelet derived growth factor beta polypeptide (oncogene SIS), Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog)

Human colon, kidney or lymph node.

Molekulargewicht: 14kDa (monomeric B chain), 31-35kDa (dimer)

Gen-ID: 5155, 1976

UniProt: P01127

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling