Dystrophin Antikörper (AA 1700-2300)

Produktnummer ABIN7859273

Dieser Maus Monoklonal Antikörper detektiert spezifisch Dystrophin in IHC. Es zeigt Reaktivität gegenüber Proben von Human und Hund.

Kurzübersicht für Dystrophin Antikörper (AA 1700-2300) (ABIN7859273)

Target: Dystrophin (DMD)

Reaktivität: Human, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Dystrophin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: DMD-6270

Produktdetails anti-Dystrophin Antikörper

Bindungsspezifität: AA 1700-2300

Verwendungszweck: Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy) Antibody

Spezifität: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1700-2300) of human DMD (exact sequence is proprietary).

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Dystrophin

Target: Dystrophin (DMD)

Andere Bezeichnung: Dystrophin

Hintergrund:

BMD, CMD3B, Duchenne muscular dystrophy (DMD), Dystrophin, Muscular dystrophy Duchenne and Becker types

Human skeletal muscle and heart muscle tissues (IHC).

Molekulargewicht: 427kDa

Gen-ID: 1756, 495912

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development