Rekombinanter HLA-ABC Antikörper (AA 100-300)

Produktnummer ABIN7864329

Der Kaninchen Monoklonal anti-HLA-ABC Antikörper wird verwendet zum Nachweis von HLA-ABC in Proben von Human und Meerschweinchen. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter HLA-ABC Antikörper (AA 100-300) (ABIN7864329)

Target: HLA-ABC

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Meerschweinchen

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HLA-ABC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: MHC-I-8366R

Produktdetails anti-HLA-ABC Antikörper

Bindungsspezifität: AA 100-300

Verwendungszweck: Recombinant HLA Class 1 ABC (MHC I) Antibody

Spezifität: Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class 79oΩ 79oΩ, class 79oΩ 79oΩ and class 79oΩ 79oΩ gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex 79oΩ 79oΩ (MHC 79oΩ 79oΩ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC 79oΩ 79oΩ is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC 79oΩ 79oΩmolecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa100-300) of human HLA-I protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu HLA-ABC

Target: HLA-ABC

Andere Bezeichnung: HLA Class 1 ABC

Hintergrund:

Antigen Presenting Molecule, Cw*1701, D6S204, FLJ27082, HLA A, HLA B, HLA C, HLA class 1 A, HLA class 1 B, HLA class 1 C, HLA JY3, HLAA, HLAB, HLAC, HLC C, Human Leucocyte Antigen C, Major Histocompatibility Complex Class I A, Major Histocompatibility Complex Class I B, Major Histocompatibility Complex Class I C,

HOP-92, Tonsil, Raji, Hep G2 or lymph node. Human Lung, Human Liver or THP-1

Molekulargewicht: 40/41kDa

Gen-ID: 3105, 3106, 3107

UniProt: P01889, P30443, P30499

Pathways: T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints