Rekombinanter TARDBP Antikörper (C-Term)

Produktnummer ABIN7864454

Der Kaninchen Monoklonal anti-TARDBP Antikörper wird verwendet zum Nachweis von TARDBP in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter TARDBP Antikörper (C-Term) (ABIN7864454)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: TARDP-9299R

Produktdetails anti-TARDBP Antikörper

Bindungsspezifität: C-Term

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant TARDBP TAR DNA binding protein / TDP43 Antibody

Spezifität: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment within human TDP43 aa 200 to the C-terminus.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: TARDBP TAR DNA binding protein

Hintergrund:

TARDBP, TAR DNA binding protein 43 antibody, ALS10

Human cerebrum or colon. Skin

Molekulargewicht: 44kDa

Gen-ID: 23435, 231829

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion